학술논문
Stereoselective Palladium‐Catalyzed Approach to Vitamin D3 Derivatives in Protic Medium.
Document Type
Article
Author
Source
Subject
*PALLADIUM
*CHOLECALCIFEROL
*NUCLEAR magnetic resonance
*DENSITY functional theory
*INFRARED spectra
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Language
ISSN
0947-6539
Abstract
Abstract: We describe an efficient convergent synthesis of vitamin D3 metabolites and analogues. The synthetic strategy relies on a tandem Pd‐catalyzed A‐ring closure and Suzuki–Miyaura coupling to the CD‐side chain component to set directly the vitamin D triene system under protic conditions. This strategy enables rapid access to vitamin D3 and 3‐epi‐vitamin D3 metabolites and analogues modified at the side chain for biological evaluation and structural and metabolic studies. [ABSTRACT FROM AUTHOR]