학술논문
Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations.
Document Type
Article
Author
Hou, Kangcheng; Gogarten, Stephanie; Kim, Joohyun; Hua, Xing; Dias, Julie-Alexia; Sun, Quan; Wang, Ying; Tan, Taotao; Group, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Methods Working; Atkinson, Elizabeth G; Martin, Alicia; Shortt, Jonathan; Hirbo, Jibril; Li, Yun; Pasaniuc, Bogdan; Zhang, Haoyu
Source
Subject
*HEALTH equity
*PHENOTYPES
*GENOTYPES
*
*
Language
ISSN
1367-4803
Abstract
Summary Admixed populations, with their unique and diverse genetic backgrounds, are often underrepresented in genetic studies. This oversight not only limits our understanding but also exacerbates existing health disparities. One major barrier has been the lack of efficient tools tailored for the special challenges of genetic studies of admixed populations. Here, we present admix-kit, an integrated toolkit and pipeline for genetic analyses of admixed populations. Admix-kit implements a suite of methods to facilitate genotype and phenotype simulation, association testing, genetic architecture inference, and polygenic scoring in admixed populations. Availability and implementation Admix-kit package is open-source and available at https://github.com/KangchengHou/admix-kit. Additionally, users can use the pipeline designed for admixed genotype simulation available at https://github.com/UW-GAC/admix-kit_workflow. [ABSTRACT FROM AUTHOR]