부산대학교 도서관

Background: Infertility is a relatively common problem that ovarian and tubular causes are the most important factors involved that can also be treated. One of its diagnostic methods is hysterosalpingography, which is a cheap and non-invasive method. The aim of this study was to compare the prophylactic effectiveness and side effects of azithromycin and doxycycline in the prevention of PID after hysterosalpingography in infertile women. Materials and Methods: This randomized, double-blind clinical trial was performed on women who underwent hysterosalpingography for the cause of infertility. Patients were randomly divided into two groups of 90. The control group received standard prophylaxis with two doses of doxycycline (100 mg) 24 hours before the procedure. The second group received prophylactic treatment with 500 mg azithromycin (single dose). Follow-up of all patients was performed 14 days after hysterosalangography for signs of pelvic inflammatory disease and possible side effects of drugs. After data collection, data analysis was performed using SPSS statistical software version 25. Results: The incidence of PID after hysterosalpingography procedure in patients receiving doxycycline and azithromycin was 6.7% and 13.3%, respectively. No significant difference was found between the incidence of PID using the prophylactic antibiotics in the two groups (P = 0.13). Complications of prophylactic antibiotics were reported only in patients receiving doxycycline, including nausea (10%), vomiting (3.3%), and abdominal pain (3.3%). In the azithromycin group, 1.1% had nausea and 2.2% had diarrhea, which showed a significant difference between the side effects of the prophylactic antibiotics in the two groups (P = 0.004). There was a significant difference between patients' satisfaction with the use of prophylactic antibiotics in the two groups (P = 0.002). Also, the low level of satisfaction in the doxycycline group compared to the azithromycin group was due to gastrointestinal side effects in the first group. Conclusion: Administration of doxycycline prophylactic antibiotic in the prevention of PID infection was not significantly different compared with azithromycin. The incidence of PID was slightly higher in patients receiving azithromycin than in doxycycline. Patients' satisfaction with doxycycline was lower due to gastrointestinal side effects when compared with patients receiving azithromycin who had no gastrointestinal side effects. [ABSTRACT FROM AUTHOR]