학술논문
Comparison of myo-inositol and metformin on glycemic control, lipid profiles, and gene expression related to insulin and lipid metabolism in women with polycystic ovary syndrome: a randomized controlled clinical trial.
Document Type
Article
Author
Source
Subject
*POLYCYSTIC ovary syndrome
*GLYCEMIC control
*LIPID metabolism
*CLINICAL trials
*GENE expression
*ANOVULATION
*DIABETES in women
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Language
ISSN
0951-3590
Abstract
本研究旨在比较肌醇和二甲双胍对多囊卵巢综合征（PCOS）女性血糖控制、血脂谱以及与胰岛素和脂质代谢相关基因表达的影响。这项随机对照试验的研究对象为53名年龄在18-40岁的PCOS女性。将受试者随机分成两组, 分别服用肌醇（n = 26）或二甲双胍（n = 27）12周。与二甲双胍相比, 肌醇的补充显著降低空腹血糖（FPG）（β-5.12 mg / dL; 95%CI, -8.09, -2.16; p =.001）, 血清胰岛素水平（β-1.4.49 mIU / mL; 95%CI,-2.28, -0.70; p <.001）, 评估胰岛素抵抗的稳态模型（β-0.36; 95%CI,-0.55,-0.17; p <.001）, 血清甘油三酯（β 12.42 mg / dL; 95%CI, -20.47, -4.37; p =.003）和VLDL-胆固醇水平（β-2.48 mg / dL; 95%CI, -4.09, -0.87; p =.003）, 显著增加定量胰岛素敏感性检查指数（β 0.006; 95%CI, 0.002,0.01; p =.006）。此外, 与二甲双胍相比, 肌醇补充可以上调过氧化物酶增殖物激活受体γ（PPAR-c）的基因表达（p =.002）。总体而言, 与二甲双胍相比, PCOS女性服用肌醇持续12周, 有益于对血糖, 甘油三酯和VLDL-胆固醇水平的控制以及PPAR-c的基因表达。 The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China. [ABSTRACT FROM AUTHOR]