학술논문
Metabonomic study on the biochemical response of spontaneously hypertensive rats to chronic taurine supplementation using 1 H NMR spectroscopic urinalysis.
Document Type
Article
Source
Subject
*METABOLOMICS
*HYPERTENSION
*TAURINE
*NUCLEAR magnetic resonance spectroscopy
*LABORATORY rats
*URINALYSIS
*BIOCHEMISTRY
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Language
ISSN
0731-7085
Abstract
Highlights: [•] Chronic taurine treatment changed urinary metabolite profiles in hypertensive rats. [•] Time-dependent metabolic changes occurred with a hypotensive effect. [•] Metabolic acidosis was suggested with decreased citric acid cycle intermediates. [•] The modulation of the intestinal microbial metabolism was observed. [•] 1H NMR metabonomics of hypertensive rats was shown to be a promising approach. [ABSTRACT FROM AUTHOR]