부산대학교 도서관

Importantly, the DKFZ classifier raises the awareness that DNA methylation data may still be relevant in unmatched cases with low tumor content or low DNA quality. DNA methylation profiling improves routine diagnosis of paediatric central nervous system tumours: a prospective population-based study. Abbreviations ATRX -Thalassemia/mental retardation and X-linked CDK4 cyclin-dependent kinase 4 CDKN2A cyclin-dependent kinase inhibitor 2A CNS central nervous system DKFZ Deutsches Krebsforschungszentrum EGFR epidermal growth factor receptor FFPE formalin-fixed paraffin-embedded FLAIR fluid-attenuated inversion recovery GBM RTK I glioblastoma multiforme receptor tyrosine kinase I HGAP high-grade astrocytomas with piloid features IDAT intensity data IDH1 isocitrate dehydrogenase 1 MTAP methylthioadenosine phosphorylase MYCN MYCN proto-oncogene Olig2 oligodendrocyte transcription factor 2 PDGFRA platelet-derived growth factor receptor PPM1D protein phosphatase Mg2+/Mn2+-dependent 1D t-SNE t-distributed stochastic neighbor embedding TERT telomerase reverse transcriptase UMAP uniform manifold approximation and projection WHO World Health Organization Genome-wide analysis of the DNA methylome has become one of the most important modalities for the integrated diagnosis of central nervous system (CNS) tumors, as demonstrated by the inclusion of this analysis in the fifth edition of the World Health Organization classification (WHO CNS5). [Extracted from the article]