학술논문
Effect of Aluminum, Iron, and Zinc Ions on the Assembly of Microtubules from Brain Microtubule Proteins.
Document Type
Article
Author
Source
Subject
*ALUMINUM
*MICROTUBULES
*ZINC
*IRON
*PROTEINS
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Language
ISSN
0007-4888
Abstract
Al, Fe, and Zn ions can disturb microtubule assembly from tubulin and microtubuleassociated proteins in rat brain. The main structural forms of these microtubules are rings and tangled bundles. These structures are formed only in the presence of Al and Fe ions. Therefore, Zn ions can be excluded from possible causes of structural abnormalities in microtubules during Alzheimer's disease. Al ions are the most probable etiological cause of Alzheimer's disease. The concentration of Al ions affecting the structure of microtubules is one order of magnitude lower than that of Fe ions (10 and 100 μM, respectively), which corresponds to their brain concentration reported in Alzheimer's disease. [ABSTRACT FROM AUTHOR]