학술논문
A Bivalent Human Norovirus Vaccine Induces Homotypic and Heterotypic Neutralizing Antibodies.
Document Type
Article
Author
Source
Subject
*NOROVIRUSES
*VACCINE immunogenicity
*IMMUNOGLOBULINS
*VIRUS-like particles
*VACCINES
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Language
ISSN
0022-1899
Abstract
A GII.2 outbreak in an efficacy study of a bivalent virus-like particle norovirus vaccine, TAK-214, in healthy US adults provided an opportunity to examine GII.4 homotypic vs GII.2 heterotypic responses to vaccination and infection. Three serologic assays—virus-like particle binding, histoblood group antigen blocking, and neutralizing—were performed for each genotype. Results were highly correlated within a genotype but not between genotypes. Although the vaccine provided protection from GII.2-associated disease, little GII.2-specific neutralization occurred after vaccination. Choice of antibody assay can affect assessments of human norovirus vaccine immunogenicity. [ABSTRACT FROM AUTHOR]