학술논문
Reductant‐Free Cross‐Electrophile Synthesis of Di(hetero)arylmethanes by Palladium‐Catalyzed Desulfinative C−C Coupling.
Document Type
Article
Author
Source
Subject
*COUPLING reactions (Chemistry)
*BENZYL halides
*SONOGASHIRA reaction
*ARYL halides
*BENZYL alcohol
*PALLADIUM catalysts
*ELECTROPHILES
*PSEUDOHALIDES
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Language
ISSN
0044-8249
Abstract
An efficient Pd‐catalyzed one‐pot desulfinative cross‐coupling to access medicinally relevant di(hetero)arylmethanes is reported. The method is reductant‐free, and involves a sulfinate transfer reagent and a Pd‐catalyst mediating the union of two electrophilic coupling partners; a (hetero)aryl halide and a benzyl halide. We establish for the first time that benzyl sulfinates, generated in situ, undergo efficient Pd‐catalyzed desulfinative cross‐coupling with (hetero)aryl halides to generate di(hetero)arylmethanes. The reaction can be extended to benzylic pseudohalides derived from benzyl alcohols. The reactions are straightforward to perform and scalable, and all reaction components are commercially available. [ABSTRACT FROM AUTHOR]