학술논문
The Role of Fas-FasL Signaling Pathway in Induction of Apoptosis in Patients with SulfurMustard-Induced Chronic Bronchiolitis.
Document Type
Article
Author
Source
Subject
*APOPTOSIS
*LUNG diseases
*BRONCHIOLE diseases
*MUSTARD gas
*BRONCHOALVEOLAR lavage
*CASE-control method
*CONTROL groups
*CELL metabolism
*ENZYME-linked immunosorbent assay
*PATIENTS
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Language
ISSN
1687-8191
Abstract
Sulfur mustard (SM) is an alkylating agent that induces apoptosis and necrosis in cells. Fas-Fas ligand (FasL) interaction could induce apoptosis as well. In this study, it was hypothesized that apoptosis might play an important role in the pathogenesis of SM-induced lung injury via Fas-FasL signaling pathway. In a case-control study, Fas and FasL levels, caspase-3 activity and percent of apoptotic cells were measured in bronchoalveolar lavage (BAL) fluid of patients 20 years after exposure to sulfur mustard and compared with the control group. Results showthat Fas and FasL levels were significantly higher in BAL fluid cells in patients group compared with the control (P = .001). No significant differences were observed between mild and moderate-severe groups. BAL fluid cells caspase-3 activity was not significantly different among the mild, moderate-severe, and control groups. The data suggest that Fas-FasL-induced apoptosis was impaired in BAL fluid cells of SM-exposed patients which might be one of the initiators of pathogenesis in SM-induced lung injury in these patients. [ABSTRACT FROM AUTHOR]