학술논문
The Effect of Polysaccharide Plugs on In Vitro Release Kinetics of Drug From Pulsatile Device and Evaluation of Its In Vivo Targeting Efficiency.
Document Type
Article
Source
Subject
*POLYSACCHARIDES
*PHARMACOKINETICS
*TARGETED drug delivery
*DRUG efficacy
*HEART assist devices
*MICROSPHERES
*PARTICLE size distribution
*MEDICAL polymers
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Language
ISSN
0091-4037
Abstract
The objective was to investigate the effect of different polysaccharide plugs on pulsatile device of Aceclofenac. The Aceclofenac microspheres were prepared in four batches, with Eudragit L-100 and S-100 (1:2) by varying drug to polymer ratio and evaluated for the particle size, drug content, and in vitro release profile and from the obtained results; one better formulation was selected for further fabrication of Pulsatile device. In vitro release mechanism of pulsatile device studied with different kinetics model. The X-ray study on humans pointed out the capability of the system to release drug in colon region. [ABSTRACT FROM PUBLISHER]