학술논문
Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia.
Document Type
Article
Author
Source
Subject
*STAT proteins
*ADAPTOR proteins
*TRANSCRIPTION factors
*HEALTH outcome assessment
*LYMPHOBLASTIC leukemia treatment
*LABORATORY mice
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Language
ISSN
1042-8194
Abstract
The article reports on research which investigated whether blocking signal transducer & activator transcription protein (STAT3) function has anti-tumor activity in vivo in T-cell acute lymphoblastic leukemia (T-ALL) induced by the high mobility group A1 (HMGA1) oncogene. Researchers investigated the therapeutic regimen with HMGA1 transgenic mice. They found that nanoparticle delivery of STAT3 G-quartet oligodeoxynucleotides (GQ-ODNs) has anti-leukemia effects in an HMGA1 transgenic model of aggressive T-ALL.