학술논문
Understanding the Molecular Basis of iPSC Reprogrammed Cells to Fulfil Their Expectations in Future Clinical Applications.
Document Type
Article
Source
Subject
*PLURIPOTENT stem cells
*INDUCED pluripotent stem cells
*CLINICAL medicine
*EMBRYONIC stem cells
*SOMATIC cells
*STEM cell research
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Language
ISSN
2073-4409
Abstract
10.1182/blood.V98.9.2615 15 Jakob M., Hambrecht M., Spiegel J.L., Kitz J., Canis M., Dressel R., Streckfuss-Bömeke K. Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Show Comparable Functionality to Their Autologous Origin. Therefore, patient-derived iPSCs show great potential in the field of personalized medicine although future efforts should focus on the improvement of the iPSCs derived cells to resemble more derived accurately mature cells. Ideally, cell replacement therapies will be done with autologous cells although as a counterpart aged cells retain their DNA mutations during reprogramming [[12]]. [Extracted from the article]