학술논문

Mitochondrial Biomarkers in the Omics Era: A Clinical-Pathophysiological Perspective.
Document Type
Article
Source
International Journal of Molecular Sciences. May2024, Vol. 25 Issue 9, p4855. 14p.
Subject
*BIOMARKERS
*MITOCHONDRIA
*METABOLOMICS
*ARCHAEOLOGICAL human remains
*PUBLISHED articles
*PROTEOMICS
Language
ISSN
1661-6596
Abstract
Mitochondrial diseases (MDs) affect 4300 individuals, with different ages of presentation and manifestation in any organ. How defects in mitochondria can cause such a diverse range of human diseases remains poorly understood. In recent years, several published research articles regarding the metabolic and protein profiles of these neurogenetic disorders have helped shed light on the pathogenetic mechanisms. By investigating different pathways in MDs, often with the aim of identifying disease biomarkers, it is possible to identify molecular processes underlying the disease. In this perspective, omics technologies such as proteomics and metabolomics considered in this review, can support unresolved mitochondrial questions, helping to improve outcomes for patients. [ABSTRACT FROM AUTHOR]