학술논문
Association between apolipoprotein E ℇ4 allele and apathy in probable Alzheimer's disease.
Document Type
Article
Author
Source
Subject
*DEMENTIA
*ALZHEIMER'S disease
*SYMPTOMS
*APOLIPOPROTEIN E
*APOLIPOPROTEINS
*GENETIC polymorphisms
*GENETIC research
*
*
*
*
*
*
Language
ISSN
0001-690X
Abstract
Objective: There have been inconclusive results to date on the association between the Apolipoprotein E (ApoE) genotype and neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD). We investigated whether ApoE ℇ4 allele is associated with NPS in probable AD. Method: Data for 197 subjects with probable AD were analysed. The Neuropsychiatric Inventory was used to evaluate the frequency and severity of NPS. Multiple logistic regression models were used to test the association between ApoE genotype and NPS in AD. Results: The ApoE ℇ3/3 genotype was present in 52.3%, ℇ3/4 in 44.1%, and ℇ4/4 in 3.6% of patients. ApoE ℇ4 carriers showed a higher frequency of apathy than non-carriers. After multiple adjustments, the ApoE ℇ4 allele was significantly associated with apathy. Conclusion: Our results suggest a relationship between the ApoE ℇ4 allele and apathy in patients with AD. [ABSTRACT FROM AUTHOR]