학술논문
Dehydrative Cp*Co(III)-Catalyzed C-H Bond Allenylation.
Document Type
Article
Source
Subject
*CARBON-hydrogen bonds
*ALLENE
*NUCLEOPHILES
*COBALT
*ALKYNES
*
*
*
*
Language
ISSN
1523-7060
Abstract
An efficient, unprecedented reactivity of Cp*Co(III) for the synthesis of tetrasubstituted allenes under mild conditions is disclosed. Electron-rich and highly nucleophilic cobalt facilitates the dehydrative C-H bond allenylation directly from propargylic alcohols without any derivatization. The reaction proceeds via reversible cyclometalation followed by alcohol-directed regioselective alkyne insertion and β-hydroxy elimination to provide the tetrasubstituted allenes. [ABSTRACT FROM AUTHOR]