학술논문
Synthesis and anti-influenza activity of 2-cyanoethoxy and 2-(1 H-tetrazol-5-yl)ethoxy derivatives of dammarane-type triterpenoids.
Document Type
Article
Author
Source
Subject
*CHEMICAL synthesis
*DAMMARANES
*TRITERPENOIDS
*AZIDATION
*ANTIVIRAL agent synthesis
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Language
ISSN
1070-4280
Abstract
A series of 3-(2-1 Н-tetrazol-5-ylethoxy- and 2-1 Н-tetrazol-5-ylethoxyimino) derivatives of dammarane triterpenoids was synthesized by azidation of 3-(2-cyanoethoxy- and 2-cyanoethoxyimino)-dammaranes. The anti-influenza activity of the prepared tetrazolyldammaranes and intermediate compounds against influenza virus А H1N1 was tested. A considerable antiviral activity was observed for 20(S)-3-(2-1 Н-tetrazol-5-ylethoxyimino)-25,26,27-trinor-20,24-olidedammarane (SI 26). [ABSTRACT FROM AUTHOR]