학술논문
Psychosis and substance abuse increase the COVID-19 mortality risk.
Document Type
Article
Author
Catalan, Ana; Aymerich, Claudia; Bilbao, Amaia; Pedruzo, Borja; Pérez, José Luis; Aranguren, Nerea; Salazar de Pablo, Gonzalo; Hedges, Emily; Gil, Patxi; Segarra, Rafael; González-Pinto, Ana; Fernández-Rivas, Aranzazu; Inchausti, Lucía; McGuire, Philip; Fusar-Poli, Paolo; González-Torres, Miguel Ángel
Source
Subject
*STATISTICS
*OBESITY
*PERSONALITY disorders
*SUBSTANCE abuse
*COVID-19
*CONFIDENCE intervals
*NEUROLOGICAL disorders
*ENDOCRINE diseases
*PSYCHOSES
*MULTIPLE regression analysis
*MULTIVARIATE analysis
*AGE distribution
*RETROSPECTIVE studies
*ACQUISITION of data
*RISK assessment
*SEX distribution
*ARTIFICIAL respiration
*KIDNEY diseases
*METABOLIC disorders
*LIVER diseases
*HOSPITAL care
*RESEARCH funding
*MEDICAL records
*DESCRIPTIVE statistics
*AFFECTIVE disorders
*SOCIODEMOGRAPHIC factors
*LOGISTIC regression analysis
*STATISTICAL models
*ODDS ratio
*DATA analysis software
*TUMORS
*ANXIETY disorders
*COMORBIDITY
*EATING disorders
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Language
ISSN
0033-2917
Abstract
Background: The coronavirus disease 2019 (COVID-19) pandemic has been a global challenge. High mortality rates have been reported in some risk groups, including patients with pre-existing mental disorders. Methods: We used electronic health records to retrospectively identify people infected due to COVID-19 (between March 2020 and March 2021) in the three territories of the Basque Country. COVID-19 cases were defined as individuals who had tested positive on a reverse transcription-polymerase chain reaction (PCR) test. Univariate and multivariate logistic regression models and multilevel analyses with generalized estimated equations were used to determine factors associated with COVID-19-related mortality and hospital admission. Results: The COVID-19 mortality rate was increased for patients with psychotic disorders [odds ratio (OR) adjusted: 1.45, 95% confidence interval (CI) (1.09–1.94), p = 0.0114] and patients with substance abuse [OR adjusted: 1.88, 95% CI (1.13–3.14, p < 0.0152)]. The mortality rate was lower for patients with affective disorders [OR adjusted: 0.80, 95% CI (0.61–0.99), p = 0.0407]. Hospital admission rates due to COVID-19 were higher in psychosis [OR adjusted: 2.90, 95% CI (2.36–3.56), p < 0.0001] and anxiety disorder groups [OR adjusted: 1.54, 95% CI (1.37–1.72), p < 0.0001]. Among admitted patients, COVID-19 mortality rate was decreased for those with affective disorders rate [OR adjusted: 0.72, 95% CI (0.55–0.95), p = 0.0194]. Conclusions: COVID-19-related mortality and hospitalizations rates were higher for patients with a pre-existing psychotic disorder. [ABSTRACT FROM AUTHOR]