학술논문

Renin as a Prognostic and Predictive Biomarker in Sepsis: More Questions Than Answers?
Document Type
Article
Source
Critical Care Medicine. Mar2024, Vol. 52 Issue 3, p509-512. 4p.
Subject
*CARDIOGENIC shock
*INTRA-aortic balloon counterpulsation
*RENIN
*HEART assist devices
*SEPSIS
*BIOMARKERS
Language
ISSN
0090-3493
Abstract
This article explores the potential use of renin as a biomarker in sepsis. Renin is an enzyme involved in regulating various physiological processes. Some studies have found associations between renin levels and sepsis outcomes, including mortality. However, these studies have limitations such as small sample sizes and lack of external validation. While renin shows promise as a biomarker, further research is needed to confirm its usefulness in clinical care. The article also discusses the potential use of renin levels to guide the administration of angiotensin II in septic shock, but more research is needed to determine reference ranges and thresholds for clinical action. Overall, there is a need for a better understanding of the renin-angiotensin system and the development of biomarkers to inform clinical decision-making. [Extracted from the article]