부산대학교 도서관

Simple Summary: Epicardial adipose tissue radio intensity and myocardial extracellular volume in computed tomography were investigated and evaluated at disease onset and after chemotherapy in patients with follicular lymphoma treated with R-CHOP and R-bendamustine regimens. The different radiomic changes in epicardial adipose tissue were evaluated in a cohort of patients treated with an anthracycline and steroid-containing regimen (R-CHOP) compared to a cohort of patients treated with R-bendamustine. Similarly, myocardial extracellular volume was assessed as an early imaging marker of myocardial fibrosis and thus of cardiological damage in the two different populations. This study analysis aims to detect the potential role of epicardial adipose tissue density and myocardial extracellular volume as early biomarkers of cardiotoxicity by comparing two valid chemo-immunotherapy regimens in follicular lymphoma patients. The aim of this study is to evaluate changes in epicardial adipose tissue (EAT) and cardiac extracellular volume (ECV) in patients with follicular lymphoma (FL) treated with R-CHOP-like regimens or R-bendamustine. We included 80 patients with FL between the ages of 60 and 80 and, using computed tomography (CT) performed at onset and at the end of treatment, we assessed changes in EAT by measuring tissue density at the level of the cardiac apex, anterior interventricular sulcus and posterior interventricular sulcus of the heart. EAT is known to be associated with metabolic syndrome, increased calcium in the coronary arteries and therefore increased risk of coronary artery disease. We also evaluated changes in ECV, which can be used as an early imaging marker of cardiac fibrosis and thus myocardial damage. The R-CHOP-like regimen was associated with lower EAT values (p < 0.001), indicative of a less active metabolism and more adipose tissue, and an increase in ECV (p < 0.001). Furthermore, in patients treated with anthracyclines and steroids (R-CHOP-like) there is a greater decrease in ejection fraction (EF p < 0.001) than in the R-B group. EAT and ECV may represent early biomarkers of cardiological damage, and this may be considered, to our knowledge, the first study investigating radiological and cardiological parameters in patients with FL. [ABSTRACT FROM AUTHOR]