학술논문
Detecting Vascular Biosignatures with a Colloidal, Radio-Opaque Polymeric Nanoparticle.
Document Type
Article
Author
Source
Subject
*COLLOIDAL crystals
*TOMOGRAPHY
*NANOPARTICLES
*POLYMERIC composites
*ORGANIC conductors
*ORGANIC synthesis
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Language
ISSN
0002-7863
Abstract
A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several- fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range. [ABSTRACT FROM AUTHOR]