학술논문
Dietary intake of meat, fruits, vegetables, and selective micronutrients and risk of bladder cancer in the New England region of the United States.
Document Type
Article
Author
Source
Subject
*MICRONUTRIENTS
*BLADDER cancer risk factors
*DIET
*LOGISTIC regression analysis
*CASE-control method
*MUTAGENS
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Language
ISSN
0007-0920
Abstract
Background:Despite many studies on diet and bladder cancer, there are areas that remain unexplored including meat mutagens, specific vegetable groups, and vitamins from diet.Methods:We conducted a population-based case-control study of bladder cancer in Maine, New Hampshire, and Vermont. A total of 1171 cases were ascertained through hospital pathology records and cancer registries from 2001 to 2004. Overall, 1418 controls were identified from the Department of Motor Vehicles (<65 years) and Center for Medicaid and Medicare Services (65-79 years) and were frequency-matched to cases by state, sex, and age (within 5 years). Diet was assessed with a self-administered Diet History Questionnaire. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI).Results:Processed meat intake was positively associated with bladder cancer (highest vs lowest quartile OR: 1.28; 95% CI: 1.00-1.65; Ptrend=0.035), with a stronger association for processed red meat (OR: 1.41; 95% CI: 1.08-1.84; Ptrend=0.024). There were no associations between intake of fruits or vegetables and bladder cancer. We did, however, observe an inverse association with vitamin B12 intake (OR: 0.77; 95% CI: 0.61-0.99; P=0.019).Conclusion:Vitamin B12 from diet may be protective against bladder cancer, whereas consuming processed meat may increase risk. [ABSTRACT FROM AUTHOR]