학술논문
Clinical response of CARD14‐associated papulosquamous eruption to an anti‐interleukin‐17A antibody.
Document Type
Article
Author
Source
Subject
*KILLER cells
*PITYRIASIS rubra
*INFORMED consent (Medical law)
*
*
Language
ISSN
0007-0963
Abstract
To further investigate the impact of systemic inflammation on CAPE and the response to IL-17A inhibition, we performed blood immunophenotyping in patient III.1 before, and after 1 and 2 months of treatment. Here we present another family with CARD14-associated papulosquamous eruption, which is characterized by mutations in CARD14 and skin lesions resembling psoriasis and pityriasis rubra pilaris. We show beneficial therapeutic response to anti-IL17A treatment in one patient and performed immunomonitoring of our patient, exhibiting enhanced pSTAT3 levels in T cells before treatment, which normalized after treatment. [Extracted from the article]