학술논문
Exploration of whole genome and transcriptome sequencing data lacks evidence for oncogenic viral elements to drive the pathogenesis of T-cell prolymphocytic leukemia.
Document Type
Article
Author
Source
Subject
*WHOLE genome sequencing
*T cells
*HEPATITIS C
*HTLV-I
*EPSTEIN-Barr virus
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Language
ISSN
1042-8194
Abstract
As the tumor cells lacked detectable traces of EBV also by PCR, our results suggest that the patient was infected with EBV at some point, but the EBV infection was not evident in T-PLL cells. Instead, EBV antigens, EBNA3C and LMP1 were found in T-PLL cells which suggests that EBV infection might affect tumor growth in T-PLL [[18]]. Although our study shows no strong evidence of tumorigenic viral involvement in T-PLL pathogenesis, we cannot exclude a hit-and-run mechanism in which viruses were active at an initiating phase of T-PLL pathogenesis but then get lost during disease evolution, as it has been proposed for some EBV-positive lymphomas [[29]]. [Extracted from the article]