부산대학교 도서관

Anti-prion effects of cellulose ether (CE) are reported in rodents, but the molecular mechanism is fully unknown. Here, we investigated the genetic background of CE effectiveness by proteomic and genetic analysis in mice. Proteomic analysis in the two mouse lines showing a dramatic difference in CE effectiveness revealed a distinct polymorphism in the glia maturation factor β gene. This polymorphism was significantly associated with the CE effectiveness in various prion-infected mouse lines. Sequencing of this gene and its vicinity genes also revealed several other polymorphisms that were significantly related to the CE effectiveness. These polymorphisms are useful as genetic markers for finding more suitable mouse lines and exploring the genetic factors of CE effectiveness. • Anti-prion effects of cellulose ether vary among mouse lines. • Cox proportional hazards model is useful for evaluating the effects. • Glia maturation factor β polymorphisms significantly correlate with the effects. • The polymorphisms are genetic markers of cellulose ether effectiveness in mice. [ABSTRACT FROM AUTHOR]