학술논문
Doravirine Concentrations and Human Immunodeficiency Virus Type 1 RNA in the Genital Fluids of Virologically Suppressed Adults Switching to Doravirine Plus Emtricitabine/Tenofovir Alafenamide.
Document Type
Article
Author
Source
Subject
*HIV infections
*THERAPEUTICS
*HIV-positive persons
*SECRETION
*COMBINATION drug therapy
*VIRAL load
*SEMEN analysis
*CERVIX uteri
*VAGINA
*EMTRICITABINE-tenofovir
*NON-nucleoside reverse transcriptase inhibitors
*ADULTS
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Language
ISSN
1058-4838
Abstract
Doravirine (DOR) concentrations and HIV-1 RNA were evaluated in genital fluids from adults with HIV on stable therapy who switched to DOR + FTC/TAF. High protein-unbound DOR concentrations were observed in both seminal plasma and cervicovaginal fluid. DOR + FTC/TAF maintained viral suppression in genital fluids in all but 1 participant. [ABSTRACT FROM AUTHOR]