학술논문
Total and Unbound Doravirine Concentrations and Viral Suppression in CSF.
Document Type
Article
Author
Source
Subject
*HIV infections
*HIV-positive persons
*CLINICAL trials
*VIRAL load
*NON-nucleoside reverse transcriptase inhibitors
*CEREBROSPINAL fluid
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*
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Language
ISSN
1058-4838
Abstract
We determined total and unbound concentrations of doravirine (DOR) in cerebrospinal fluid and blood plasma. Total and unbound DOR concentrations in cerebrospinal fluid exceeded the half-maximal effective concentration against wild-type virus (5.1 ng/mL) in all patients, suggesting that DOR may contribute to inhibit viral replication in this compartment. [ABSTRACT FROM AUTHOR]