학술논문
Ovarian Cyst Fluids Are a Cache of Tumor Biomarkers That Include Calgranulin A and Calgranulin B Isoforms.
Document Type
Article
Author
Source
Subject
*OVARIAN cysts
*CARRIER proteins
*BIOMARKERS
*CANCER cells
*TIME-of-flight mass spectrometry
*CYTOLOGY
*BIOCHEMISTRY
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Language
ISSN
0735-7907
Abstract
SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A ( m/z 10847) and two isoforms of calgranulin B ( m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors. [ABSTRACT FROM AUTHOR]