학술논문
Perillyl alcohol suppresses antigen-induced immune responses in the lung.
Document Type
Article
Author
Source
Subject
*PERILLYL alcohol
*ANTIGENS
*IMMUNE response
*LUNG physiology
*ISOPENTENOIDS
*MEVALONATE kinase
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Language
ISSN
0006-291X
Abstract
Highlights: [•] Perillyl alcohol (POH) is an isoprenoid which inhibits the mevalonate pathway. [•] We examined whether POH suppresses immune responses with a mouse model of asthma. [•] POH treatment during sensitization suppressed Ag-induced priming of CD4+ T cells. [•] POH suppressed airway eosinophila and cytokine production in thoracic lymph nodes. [ABSTRACT FROM AUTHOR]