부산대학교 도서관

The research articles describe new and interesting methodological approaches, identify feasible therapeutic targets for certain tumor types, and unveil a new small molecule able to inhibit a specific oncogene. The isolation of the first human oncogene (HRAS), a critical breakthrough in cancer research, has occurred over forty years ago, and the identification of new pathogenic oncogenes has continuously grown since. Strikingly, both in vitro and in vivo experiments demonstrated a significant reduction in CML tumor cell proliferation and tumor growth, thus providing a proof-of-concept for the therapeutic potential of a CRISPR-trap system as a novel strategy for gene elimination in hematological neoplasms. [Extracted from the article]