학술논문
Weight‐adapted fixed‐dose combined adult antiretroviral tablets for HIV‐infected children.
Document Type
Article
Author
Source
Subject
*HIV infections
*VIRAL physiology
*COMBINATION drug therapy
*VIRAL load
*ANTIRETROVIRAL agents
*INDIVIDUALIZED medicine
*LAMIVUDINE
*DESCRIPTIVE statistics
*ABACAVIR
*LONGITUDINAL method
*CHILDREN
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Language
ISSN
0269-4727
Abstract
What is known and objective: Therapeutic alternatives to simplify antiretroviral therapy (ART) in HIV‐infected children are needed. We report our experience with abacavir(ABC)/lamivudine(3TC) individualized dose compounded capsules (IDCC). Comment: We present a prospective case series of HIV‐infected children who did not weigh enough to receive the adult fixed‐dose combination including ABC/3TC 600mg/300mg, and were treated with weight‐adapted ABC/3TC IDCC in Barcelona, Spain. Thirteen patients (12 girls) received ABC/3TC IDCC for a median(IQR) time of 30(17‐54) months. No significant changes were observed in CD4 cell counts, weight or height z‐scores over time. Suppression of viral replication was maintained in 7 patients with undetectable viremia at baseline. Another 5 patients achieved viral suppression with ABC/3TC IDCC‐based ART, while one non‐adherent girl did not. No adverse events related to ABC/3TC IDCC were observed. What is new and conclusion: Despite small numbers, the long‐term use of ABC/3TC IDCC was feasible, safe, and effective in the treatment of HIV‐infected children. [ABSTRACT FROM AUTHOR]