학술논문
Failures of 13-Valent Conjugated Pneumococcal Vaccine in Age-Appropriately Vaccinated Children 2-59 Months of Age, Spain.
Document Type
Journal Article
Author
Hernández, Sergi; Moraga-Llop, Fernando; Díaz, Alvaro; de Sevilla, Mariona F.; Ciruela, Pilar; Muñoz-Almagro, Carmen; Codina, Gemma; Campins, Magda; José García-García, Juan; Esteva, Cristina; Izquierdo, Conchita; González-Peris, Sebastià; Martínez-Osorio, Johanna; Uriona, Sonia; Salleras, Luis; Domínguez, Ángela; García-García, Juan José
Source
Subject
*PNEUMOCOCCAL vaccines
*CHILDREN'S hospitals
*STREPTOCOCCUS pneumoniae
*RESPIRATORY infections
*SEROTYPES
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Language
ISSN
1080-6040
Abstract
Vaccination with the 13-valent conjugated pneumococcal disease (PCV13) has reduced invasive pneumococcal disease (IPD), but there have been reports of vaccine failures. We performed a prospective study in children aged 2-59 months who received diagnoses of IPD during January 2012-June 2016 in 3 pediatric hospitals in Catalonia, Spain, a region with a PCV13 vaccination coverage of 63%. We analyzed patients who had been age-appropriately vaccinated but who developed IPD caused by PCV13 serotypes. We detected 24 vaccine failure cases. The serotypes involved were 3 (16 cases); 19A (5 cases); and 1, 6B, and 14 (1 case each). Cases were associated with children without underlying conditions, with complicated pneumonia (OR 6.65, 95% CI 1.91-23.21), and with diagnosis by PCR (OR 5.18, 95% CI 1.84-14.59). Vaccination coverage should be increased to reduce the circulation of vaccine serotypes. Continuous surveillance of cases of IPD using both culture and PCR to characterize vaccine failures is necessary. [ABSTRACT FROM AUTHOR]