학술논문
Validating the Communication and Symbolic Behavior Scales–Developmental Profile Infant–Toddler Checklist (CSBS–DP ITC) Beyond Infancy in the CDKL5 Deficiency Disorder.
Document Type
Article
Author
Source
Subject
*GOODNESS-of-fit tests
*COMMUNICATIVE competence
*RESEARCH funding
*RESEARCH methodology evaluation
*FUNCTIONAL assessment
*INFANTILE spasms
*DEVELOPMENTAL disabilities
*CAREGIVERS
*COMMUNICATIVE disorders
*COMMUNICATION
*PSYCHOMETRICS
*EPILEPSY
*RESEARCH methodology
*STATISTICAL reliability
*FACTOR analysis
RESEARCH evaluation
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Language
ISSN
0162-3257
Abstract
CDKL5 deficiency disorder (CDD) results in early-onset epilepsy and lifelong cognitive and motor impairments. With no validated measure for communication in CDD, this study evaluated the psychometric properties of the Communication and Symbolic Behavior Scales-Developmental Profile Infant Toddler Checklist (CSBS–DP ITC). Caregivers (n = 150; affected individuals aged 1–29 years) completed the CSBS-DP ITC. Distribution of scores indicated a floor effect. There was poor divergent validity for the three-factor model but goodness of fit and convergent validity data were satisfactory for the one-factor model. Individuals with poorer overall functional abilities scored lower on the CSBS-DP ITC. Test–retest reliability was excellent. The floor effect could explain the very high reliability, suggesting problems as a sensitive outcome measure in clinical trials for CDD. [ABSTRACT FROM AUTHOR]