부산대학교 도서관

Background and Objectives: Allergic transfusion reactions (ATRs) and febrile non‐haemolytic transfusion reactions (FNHTRs) are common, although their mechanisms remain unclear. Immunoglobulin E (IgE)‐mediated type I hypersensitivity may be involved in the pathogenesis of ATR. A basophil activation test (BAT) may help elucidate this process. Materials and Methods: The BAT was based on peripheral blood samples from paediatric patients with a haematological or oncological disease and on samples of residual blood products transfused in each case. Dasatinib was used to evaluate whether basophil activation was mediated by an IgE‐dependent pathway. Results: Twenty‐seven patients with and 19 patients without ATR/FNHTR were included in this study, respectively. The median BAT values associated with ATR‐ (n = 41) and FNHTR‐causing (n = 5) blood products were 22.1% (range = 6.1%–77.0%) and 27.8% (range = 15.2%–47.8%), respectively, which were higher than the median value of 8.5% (range = 1.1%–40.9%) observed in blood products without a transfusion reaction. Dasatinib suppressed basophil activity. BAT values were comparable in patients with ATR regardless of severity. Meanwhile, BAT values analysed with blood products non‐causal for ATR/FNHTR were higher in patients with ATR/FNHTR than in those without. Conclusion: The IgE‐mediated type I hypersensitivity may be involved in the pathogenesis of ATR and FNHTR. BAT analyses may help elucidate the underlying mechanisms and identify patients at risk. [ABSTRACT FROM AUTHOR]