학술논문
Evaluation of neuroretinal integrity in optical coherence tomography‐graded eyes with partial‐thickness macular holes.
Document Type
Article
Author
Source
Subject
*OPTICAL coherence tomography
*VISUAL acuity
*
Language
ISSN
1755-375X
Abstract
Purpose: To evaluate neuroretinal integrity in different subtypes of optical coherence tomography (OCT)‐graded partial‐thickness macular holes. Methods: Fovea‐centred SD‐OCT images (Cirrus, Carl Zeiss Meditec AG; Spectralis, Heidelberg Engineering GmbH) and visual acuity (VA) acquired at every visit were analysed by two retina specialists retrospectively in 71 eyes of 65 patients. Partial‐thickness macular holes were classified as lamellar macular hole (LMH), epiretinal membrane foveoschisis (ERMF) or macular pseudohole (MPH). Results: Lamellar macular hole, ERMF and MPH were diagnosed in 33 (47%), 31 (43%) and 7 (10%) eyes with a VA of 0.18 ± 0.25, 0.15 ± 0.2, and 0.06 ± 0.08 (p = 0.323), respectively. Median follow‐up time was 11 (interquartile range 4–32.5), 10 (interquartile range 5–18) and 19 (interquartile range 8–24) months in LMH, ERMF and MPH. In all subgroups, VA remained stable during the follow‐up (p = 0.652, p = 0.915 and p = 1.000). Epiretinal proliferations (EP) were present in 12 LMH and 3 ERMF. At baseline, eyes with EP had significantly worse VA (p < 0.001), wider foveal cavities (p = 0.007) and thinner foveal floors (p < 0.001) compared with eyes without EP. Twelve out of 15 eyes with EP showed exudative cystoid spaces. Among all 71 eyes, 51 remained morphologically and functionally stable during follow‐up. Conclusion: In our study cohort, EP are associated with worse VA and advanced neuroretinal tissue loss presenting with wider foveal cavities and thinner foveal floors. During the follow‐up period, VA remained stable in all entities of partial‐thickness macular holes. [ABSTRACT FROM AUTHOR]