학술논문
A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.
Document Type
Article
Author
Polimanti, Renato; Amstadter, Ananda B.; Stein, Murray B.; Almli, Lynn M.; Baker, Dewleen G.; Bierut, Laura J.; Bradley, Bekh; Farrer, Lindsay A.; Johnson, Eric O.; King, Anthony; Kranzler, Henry R.; Maihofer, Adam X.; Rice, John P.; Roberts, Andrea L.; Saccone, Nancy L.; Hongyu Zhao; Liberzon, Israel; Ressler, Kerry J.; Nievergelt, Caroline M.; Koenen, Karestan C.
Source
Subject
*POST-traumatic stress disorder
*MONOGENIC & polygenic inheritance (Genetics)
*BODY mass index
*HUMAN sexuality
*TRAUMATIC neuroses
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Language
ISSN
1756-994X
Abstract
Background: The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear. Methods: We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behaviors and functions in women. The analysis was conducted using female-specific summary statistics from large genome-wide association studies (GWAS) and a cohort of 3577 European American women (966 PTSD cases and 2611 trauma-exposed controls). We applied a high-resolution polygenic score approach and Mendelian randomization analysis to investigate genetic correlations and causal relationships. Results: We observed an inverse association of PTSD with genetically determined anthropometric traits related to body shape, independent of body mass index (BMI). The top association was related to BMI-adjusted waist circumference (WCadj; R = –0.079, P < 0.001, Q = 0.011). We estimated a relative decrease of 64.6% (95% confidence interval = 27.5–82.7) in the risk of PTSD per 1-SD increase in WCadj. MR-Egger regression intercept analysis showed no evidence of pleiotropic effects in this association (Ppleiotropy = 0.979). We also observed associations of genetically determined WCadj with age at first sexual intercourse and number of sexual partners (P = 0.013 and P < 0.001, respectively). Conclusions: There is a putative causal relationship between genetically determined female body shape and PTSD, which could be mediated by evolutionary mechanisms involved in human sexual behaviors. [ABSTRACT FROM AUTHOR]