학술논문
Guselkumab Treatment Outcomes and Persistence in a Nationwide Real-world Cohort of Patients with Plaque Psoriasis.
Document Type
Article
Author
MÄLKÖNEN, Tarja; NUUTINEN, Pauliina; HALLINEN, Taru; SOINI, Erkki; NISSINEN, Riikka; WENNERSTRÖM, Christina; RANTANEN, Tapio; HAGMAN, Johanna H.; HARVIMA, Rauno; HÖÖK-NIKANNE, Johanna; ILVES, Tiina; LINTU, Päivi; MALANIN, Ken; SORAMÄKI, Iina; TASANEN, Kaisa; TEHO, Arja; VÄHÄVIHU, Katja; ITÄLINNA, Sari; LEINONEN, Pekka; SARAJÄRVI, Piia
Source
Subject
*TREATMENT effectiveness
*PSORIASIS
*EXPOSURE therapy
*BIOTHERAPY
*TREATMENT duration
*
*
*
*
Language
ISSN
0001-5555
Abstract
Guselkumab treatment outcomes and persistence were assessed in a real-world cohort of Finnish patients with difficult-to-treat plaque psoriasis over a median follow-up of 1 year. Data on 181 patients who initiated guselkumab at the 15 study centres were collected retrospectively from the patient charts. Prior exposure to biologic therapies was common, with 56% and 35% having used at least 1 and 2 biologics, respectively. Median guselkumab treatment duration was 11 months with 21 patients (12%) discontinuing treatment during follow-up. Of 85 patients with a follow-up duration of at least 1 year, 73 (86%) were still on guselkumab at 1 year. Significant improvements during follow-up were seen in the absolute Psoriasis Area and Severity Index (PASI) scores with 32 patients (80%) having absolute PASI = 2 after a 9-14-month treatment. Guselkumab treatment was effective and treatment persistence was high in the nationwide Finnish real-life setting. [ABSTRACT FROM AUTHOR]