부산대학교 도서관

Background: Postoperative respiratory disturbances may be the result either of depression of respiratory drive, or alteration of respiratory pattern.Methods: Using an inductance plethysmograph, we continuously recorded the breathing in 52 patients for 4 h after major thoracic, abdominal, and body surface surgery. The ventilatory response to hypercapnia was measured preoperatively, and at the start and end of the observation period.Results: From a variety of statistical measures of respiratory depression, it was found that the occurrence of apnoeas (breath times >10 s), did not correlate with measures of respiratory drive, or with dose or route of administration of opioid, site of surgery, pain, or drowsiness. Instead, the incidence of apnoeas correlated most closely with measures of respiratory pattern (standard deviation of breath times (r=0.72), the mean breath time (r=0.63), approximate entropy of the breath times (r= -0.32)). Twenty-nine percent of patients had some breath times (Ttot) longer than 20 s.Conclusion: We would conclude that changes in respiratory pattern are not closely correlated with changes in traditional measures of respiratory drive. [ABSTRACT FROM AUTHOR]