학술논문
Deconstructing cancer with precision genome editing.
Document Type
Article
Source
Subject
*GENOME editing
*GENETIC mutation
*CANCER research
*SCALABILITY
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Language
ISSN
0300-5127
Abstract
Recent advances in genome editing technologies are allowing investigators to engineer and study cancer-associated mutations in their endogenous genetic contexts with high precision and efficiency. Of these, base editing and prime editing are quickly becoming gold-standards in the field due to their versatility and scalability. Here, we review the merits and limitations of these precision genome editing technologies, their application to modern cancer research, and speculate how these could be integrated to address future directions in the field. [ABSTRACT FROM AUTHOR]