학술논문

PLGA–TiO 2 as a Carrier System for Drug Release.
Document Type
Article
Source
International Journal of Molecular Sciences. Sep2022, Vol. 23 Issue 18, pN.PAG-N.PAG. 8p.
Subject
*TITANIUM dioxide nanoparticles
*DRUG carriers
*SCANNING electron microscopy
*INFRARED spectroscopy
*NANOSTRUCTURED materials
Language
ISSN
1661-6596
Abstract
This paper reports the results of the PLGA–TiO2 nanocomposite regarding the green synthesis of titanium dioxide nanoparticles using a natural extract, its characterization, and encapsulation with poly(lactic-co-glycolic acid) (PLGA). UV–visible spectrometry was used for the identification of terpenes present in the extracts. The morphology of the nanoparticles was determined by scanning electron microscopy. Infrared spectroscopy was used for the determination of functional groups, while X-ray diffraction was used to determine the crystal structure. The analysis of the extended release of the encapsulated extract in the matrix of the nanomaterial resulted in a maximum visible UV absorbance at approximately 260 nm and confirmed the synthesis of titanium dioxide nanoparticles. Moreover, terpenes enhance synthesis and stabilize titanium dioxide nanoparticles. The synthesized structures are spherical and amorphous, 44 nm in size, and encapsulated at 65 nm. [ABSTRACT FROM AUTHOR]