학술논문
Treatment of infantile fibrosarcoma associated to an abdominal aortic aneurysm with larotrectinib: a case report.
Document Type
Report
Author
Corral Sánchez, María Dolores; Galán Gómez, Víctor; Sastre Urgelles, Ana; Plaza López de Sabando, Diego; Rubio Aparicio, Pedro; Martínez Martínez, Leopoldo; Alonso Gamarra, Eduardo; Pozo Kreilinger, José Juan; Regojo Zapata, Rita María; López Gutiérrez, Juan Carlos; Antolín Alvarado, Eugenia; Gómez Martín, Felipe; Sánchez Torres, Ana María; Marín Manzano, Elena; González del Valle, Luis; Pérez-Martínez, Antonio
Source
Subject
*ABDOMINAL aortic aneurysms
*FIBROSARCOMA
*GENE fusion
*TREATMENT effectiveness
*AORTIC aneurysms
*AORTIC rupture
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Language
ISSN
0888-0018
Abstract
Infantile fibrosarcoma (IFS) is a rare pediatric tumor which often presents the ETV6-NTRK3 gene fusion. NTRK3 encodes the neurotrophin-3 growth factor receptor tyrosine kinase, a druggable therapeutic target. Selective tropomyosin receptor kinase (TRK) inhibitors, such as larotrectinib, have shown efficacy and safety in the treatment of IFS. We report a case of an abdominal IFS diagnosed in a newborn associated with an aortic aneurysm that was successfully treated with larotrectinib without relevant adverse effects. [ABSTRACT FROM AUTHOR]