학술논문
Secondary attack rates in primary and secondary school bubbles following a confirmed case: Active, prospective national surveillance, November to December 2020, England.
Document Type
Article
Author
Powell, Annabel A.; Ireland, Georgina; Baawuah, Frances; Beckmann, Joanne; Okike, Ifeanyichukwu O.; Ahmad, Shazaad; Garstang, Joanna; Brent, Andrew J.; Brent, Bernadette; Aiano, Felicity; Hargreaves, James; Langan, Sinéad M.; Mangtani, Punam; Nguipdop-Djomo, Patrick; Sturgess, Joanna; Oswald, William; Halliday, Katherine; Rourke, Emma; Dawe, Fiona; Amin-Chowdhury, Zahin
Source
Subject
*SECONDARY schools
*PRIMARY schools
*WHOLE genome sequencing
*SECONDARY school students
*GENE transfection
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Language
ISSN
1932-6203
Abstract
Background: Following the full re-opening of schools in England and emergence of the SARS-CoV-2 Alpha variant, we investigated the risk of SARS-CoV-2 infection in students and staff who were contacts of a confirmed case in a school bubble (school groupings with limited interactions), along with their household members. Methods: Primary and secondary school bubbles were recruited into sKIDsBUBBLE after being sent home to self-isolate following a confirmed case of COVID-19 in the bubble. Bubble participants and their household members were sent home-testing kits comprising nasal swabs for RT-PCR testing and whole genome sequencing, and oral fluid swabs for SARS-CoV-2 antibodies. Results: During November-December 2020, 14 bubbles were recruited from 7 schools, including 269 bubble contacts (248 students, 21 staff) and 823 household contacts (524 adults, 299 children). The secondary attack rate was 10.0% (6/60) in primary and 3.9% (4/102) in secondary school students, compared to 6.3% (1/16) and 0% (0/1) among staff, respectively. The incidence rate for household contacts of primary school students was 6.6% (12/183) and 3.7% (1/27) for household contacts of primary school staff. In secondary schools, this was 3.5% (11/317) and 0% (0/1), respectively. Household contacts were more likely to test positive if their bubble contact tested positive although there were new infections among household contacts of uninfected bubble contacts. Interpretation: Compared to other institutional settings, the overall risk of secondary infection in school bubbles and their household contacts was low. Our findings are important for developing evidence-based infection prevention guidelines for educational settings. [ABSTRACT FROM AUTHOR]