학술논문

Translating pathology in multiple sclerosis: the combination of postmortem imaging, histopathology and clinical findings.
Document Type
Article
Source
Acta Neurologica Scandinavica. Jun2009, Vol. 119 Issue 6, p349-355. 7p. 1 Color Photograph, 1 Diagram.
Subject
*HISTOPATHOLOGY
*MAGNETIC resonance imaging
*MULTIPLE sclerosis
*PREVENTIVE medicine
*STATISTICAL correlation
*CLINICAL trials
Language
ISSN
0001-6314
Abstract
Background – Studies combining postmortem magnetic resonance imaging (MRI) and histopathology have provided important insights into the abnormalities reflected by MRI. Materials and methods – A short overview of these studies applied to multiple sclerosis (MS) is provided in this review, and the Amsterdam postmortem imaging protocol is specifically highlighted. Conclusion – Postmortem MRI and histopathology correlation studies have enabled a direct translation of basic pathology in MS to the clinical setting, and have simultaneously served as a biological validation of new MRI techniques. [ABSTRACT FROM AUTHOR]