학술논문
Sensitization to isothiazolinones in the Spanish Contact Dermatitis Registry (REIDAC): 2019–2021 epidemiological situation.
Document Type
Article
Author
Hernández Fernández, Carlos Pelayo; Borrego, Leopoldo; Mercader García, Pedro; Giménez Arnau, Ana María; Sánchez Pérez, Javier; Silvestre Salvador, Juan Francisco; González Pérez, Ricardo; Sanz Sánchez, Tatiana; Sánchez Gilo, Araceli; Melé Ninot, Gemma; Zaragoza Ninet, Violeta; Miquel Miquel, Francisco Javier; Carrascosa Carrillo, José Manuel; Córdoba Guijarro, Susana; Gatica Ortega, María Elena; Ruiz González, Inmaculada; Serra Baldrich, Esther; Tous Romero, Fátima; Rodríguez Serna, Mercedes; Pastor Nieto, María Antonia
Source
Subject
*CONTACT dermatitis
*MYOCARDIAL infarction
*SKIN inflammation
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Language
ISSN
0105-1873
Abstract
Background: Current frequency and risk factors for sensitization to methylisothiazolinone (MI), methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in Spain are not well known. Objectives: To study the frequency of sensitization, risk factors and simultaneous sensitization between the four isothiazolinones. Materials and Methods: We analysed all 2019–2021 consecutive patients patch‐tested with MI (0.2% aq.), MCI/MI (0.02% aq.), BIT (0.1% pet.) and OIT (0.1% pet) within the Spanish Contact Dermatitis Registry (REIDAC). Results: A total of 2511 patients were analysed. Frequencies of sensitization were: any isothiazolinone 15.7%, MI 6.8%, MCI/MI 4.8%, BIT 3.5% and OIT 0.5%. MI and MCI/MI sensitization was associated with being occupationally active, hand dermatitis, detergents and age over 40. BIT sensitization was associated with leg dermatitis and age over 40. About one in nine MI‐positive patients were positive to BIT, whereas one in five BIT‐positive patients were positive to MI. Conclusions: Sensitization to MI, MCI/MI and BIT is still common in Spain, while sensitization to OIT is rare. Currently, sensitization to MI and MCI/MI seems to be occupationally related. Although its origin is unknown, sensitization to BIT is more frequent in patients aged over 40 years. Simultaneous sensitization between MI and BIT is uncommon. [ABSTRACT FROM AUTHOR]