학술논문
SYNTHESIS AND IN VITRO CYTOTOXIC AND ANTIVIRAL ACTIVITIES OF 1-(2,5,6-TRIDEOXY-6-HALOGENOHEPT-5-ENOFURANURONONITRILE)THYMINE AND DERIVATIVES.
Document Type
Article
Author
Source
Subject
*THYMINE
*CELL culture
*MOLECULES
*HALOGENS
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*
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Language
ISSN
1525-7770
Abstract
All 1-(2,5,6-trideoxy-6-halogenohept-5-enofuranurononitrile)thymine and their 3′-O-TBDMS derivatives have been prepared and their configuration established. Some of these compounds are endowed with a cytotoxic or cytostatic activity in cell culture. The single most important factor affecting the cytotoxicity of these compounds is the presence on the molecule of a soft (electrofugal) halogen atom. [ABSTRACT FROM AUTHOR]