학술논문
Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF.
Document Type
Article
Source
Subject
*DIMETHYLAMINE
*AROMATIC compound synthesis
*NUCLEOPHILIC substitution reactions
*CHEMICAL reactions
*HALIDES
*
*
*
*
Language
ISSN
0022-3263
Abstract
A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported. [ABSTRACT FROM AUTHOR]