학술논문
PREDICTING DRUG INTERACTIONS AND PHARMACOKINETIC VARIABILITY WITH IN VITRO METHODS: THE OLANZAPINE EXPERIENCE*.
Document Type
Article
Author
Source
Subject
*OLANZAPINE
*CYTOCHROME P-450
*
Language
ISSN
0360-2532
Abstract
Reports on predictions concerning the ability of olanzapine to interact with cytochrome P450 and its pharmacokinetic variability generated from the in vitro experiments. Identification of the human enzymes responsible for the formation of the major in vitro oxidative metabolites of olanzapine; In vitro to in vivo correlations.