학술논문
Priming of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+ T Cell Responses by Dendritic Cells Loaded with HIV-1 Proteins.
Document Type
Article
Author
Source
Subject
*HIV
*DENDRITIC cells
*T cells
*
*
Language
ISSN
0022-1899
Abstract
Proteins may serve as ideal CD8[sup +] T cell immunogens for human immunodeficiency virus type 1 (HIV-1) if they can be delivered to and processed through the human leukocyte antigen class I pathway. This study shows that human blood monocyte-derived dendritic cells loaded with liposome-complexed HIV-1 proteins and matured with CD40 ligand can prime CD8[sup +] T cells to HIV-1 in vitro. Whole HIV-1 protein in liposome may be an effective immunogen for HIV-1 vaccine protocols. [ABSTRACT FROM AUTHOR]