학술논문
O6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation is significantly less frequent in ependymal tumours as compared to malignant astrocytic gliomas.
Document Type
Other
Source
Subject
*TUMORS
*CYSTS (Pathology)
*NERVOUS system tumors
*ASTROCYTOMAS
*DNA
*
*
*
*
Language
ISSN
0305-1846
Abstract
The article presents a study related to the frequency of methylation of the O6-methylguanine-DNA methyltransferase (MGMT) in ependymal tumours and malignant astrocytic gliomas. The results of the study showed that the MGMT promoter methylation was significantly less frequent in ependymal tumours. However, it states that the significance of MGMT promoter methylation status could act as potential prognostic marker for ependymal tumour treatment in future prospective trials.