학술논문
Author Correction: Application of Mendelian randomization to explore the causal role of the human gut microbiome in colorectal cancer.
Document Type
Article
Author
Hatcher, Charlie; Richenberg, George; Waterson, Samuel; Nguyen, Long H.; Joshi, Amit D.; Carreras-Torres, Robert; Moreno, Victor; Chan, Andrew T.; Gunter, Marc; Lin, Yi; Qu, Conghui; Song, Mingyang; Casey, Graham; Figueiredo, Jane C.; Gruber, Stephen B.; Hampe, Jochen; Hampel, Heather; Jenkins, Mark A.; Keku, Temitope O.; Peters, Ulrike
Source
Subject
*GUT microbiome
*HUMAN microbiota
*COLORECTAL cancer
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Language
ISSN
2045-2322
Abstract
However, despite little evidence for genetic colocalisation for I G. Bifidobacterium i with overall and site-specific CRC, regional association plots suggest the genomic region surrounding the rs4988235 SNP is important in both abundance of I G. Bifidobacterium i and CRC risk (Fig. Whilst there was evidence for genetic colocalisation for I G. Bifidobacterium i with overall (with a posterior probability of 0.87) CRC risk and, to a lower extent, with site-specific CRC risk (posterior probabilities ranged from 0.05-0.72), regional association plots suggest the wider genomic region surrounding the rs4988235 SNP is important in both abundance of I G. Bifidobacterium i and CRC risk (Fig. [Extracted from the article]